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KMID : 0903520090520010034
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 1 p.34 ~ p.39
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Synthesis and Antimicrobial Evaluation of Sulfides, Sulfoxides, and Sulfones
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Kumar A.B.V. Kiran
Rao K.S.V. Krishna
Chandra M.Subhosh
Subha M.C.S.
Choi Yong-Lark
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Abstract
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Hydrogen peroxide, with sodium metavanadate as the catalyst, was used to achieve a highly efficient and selective oxidation of sulfides into sulfoxides and sulfones at room temperature in high yields and short reaction times. All of the sulfides oxidized into sulfoxides and sulfone derivatives were assayed for their in vitro antibacterial activities against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa, and antifungal activities against Aspergillus niger and Candida albicans. A remarkable inhibition of the growth of the bacterial and fungal strains was observed. This result suggested that the compounds are promising microbial agents.
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KEYWORD
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antimicrobial activity, hydrogen peroxide, oxidation, sulfones, sulfoxides
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